From Science Daily:
Three easy -- one could even say slow -- 5-minute walks can reverse harm caused to leg arteries during three hours of prolonged sitting, researchers report. Sitting for long periods of time is associated with risk factors such as higher cholesterol levels and greater waist circumference that can lead to cardiovascular and metabolic disease. When people sit, slack muscles do not contract to effectively pump blood to the heart. Blood can pool in the legs and affect the endothelial function of arteries, or the ability of blood vessels to expand from increased blood flow.
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Editor's note:
As a psychotherapist my job is very sedentary and at most I walk from my office twenty feet to my waiting room and back every hour when I have a new client or walk up about 15 steps to use the restroom at the top of the stairs. I got to walk more. After reading this I'm gonna. Really. I really am. Tomorrow.

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